1219804-09-7Relevant articles and documents
Deuterotelaprevir key intermediate and preparation method thereof
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Paragraph 0033-0035, (2018/05/16)
The invention discloses a deuterotelaprevir key intermediate which has a structure shown by formula (VII): FORMULA shown in the description. The invention also discloses a preparation method of the deuterotelaprevir key intermediate, wherein the preparation method comprises the following steps: with hexadeutero 4-ethyl chlorobutyrate and sodium hydroxide as reaction raw materials, performing a cyclization and hydrolysis reaction, a rearrangement reaction, a reduction reaction and a condensation reaction to obtain a deutero compound shown by the formula (VII). The deuterotelaprevir key intermediate disclosed by the invention has the advantages of reasonable design of reaction route, easiness and convenience in operation of the preparation steps and easily available reaction raw materials.