1219804-86-0

Usage

Uses

Used in Research and Development:
4-Chloroanisole--d4 is used as a research compound for studying the properties and behavior of isotopically labeled molecules in chemical reactions and biological systems. The presence of deuterium atoms in its structure allows researchers to track and analyze the compound's interactions and transformations more accurately.
Used in Analytical Chemistry:
In analytical chemistry, 4-Chloroanisole--d4 can be employed as an internal standard or a reference compound for the quantification and identification of related compounds in complex mixtures. Its isotopically labeled nature provides a distinct signature, enabling accurate measurements and comparisons.
Used in Pharmaceutical Industry:
4-Chloroanisole--d4 may also find applications in the pharmaceutical industry, where it can be used as a building block or a precursor for the synthesis of novel drugs or drug candidates. Its unique properties and isotopically labeled structure can be advantageous in the development of targeted therapies and drug delivery systems.
Used in Environmental Science:
In environmental science, 4-Chloroanisole--d4 can be utilized as a tracer compound to study the fate and transport of pollutants in the environment. Its isotopically labeled nature allows for the differentiation between natural and anthropogenic sources of similar compounds, providing valuable insights into environmental processes and pollution control strategies.
Used in Material Science:
4-Chloroanisole--d4 may also have potential applications in material science, where it could be used to study the properties and behavior of isotopically labeled materials. This information can be crucial for the development of new materials with tailored properties for various applications, such as sensors, catalysts, or advanced materials for energy storage and conversion.

Upstream product

• 553-82-2 1,3-dichloro-4-methoxybenzene 
• 87-40-1 2,4,6-trichloroanisole 
• 54887-54-6 anisole-d₈ 

Relevant academic research and scientific papers

Palauchlor: A practical and reactive chlorinating reagent

Unlike its other halogen atom siblings, the utility of chlorinated arenes and (hetero)arenes are twofold: they are useful in tuning electronic structure as well as acting as points for diversification via cross-coupling. Herein we report the invention of a new guanidine-based chlorinating reagent, CBMG or "Palauchlor", inspired by a key chlorospirocyclization en route to pyrrole imidazole alkaloids. This direct, mild, operationally simple, and safe chlorinating method is compatible with a range of nitrogen-containing heterocycles as well as select classes of arenes, conjugated π-systems, sulfonamides, and silyl enol ethers. Comparisons with other known chlorinating reagents revealed CBMG to be the premier reagent.

Electroreductive Dehalogenation of Chlorinated Aromatic Ethers. Unexpected Electrogenerated Base Catalyzed Reactions

The electroreductive dehalogenation of several mono- and polychlorinated aromatic ethers that serve as models of dioxins has been studied.The dechlorination was achieved by a simple constant-current electrolysis using a lead cathode in dimethylformamide.It was shown that 2,4,6-trichloroanisole undergoes successive dechlorination and the chlorine in the 2-position is selectively eliminated.Competitive reactions and cyclic voltammetric measurements suggested the increasing reactivity order of mono- di- trichloride for the reductive dechlorination.Use of allyl 2-chloro phenyl ether as a probe for radical cyclization indicated that free radical intermediates are of little importance.Thus, incipient radicals are immediately reduced to anionic intermediates.The electrolyses in the presence of deuterium oxide revealed proton sources for the present dechlorination.In these attempts, novel phenomena due to electrogenerated base (EGB) were found: di- and trichlorides underwent an unexpected overincorporation of deuterium in their dechlorinated products; a selective formation of Z-enol ethers from the allylic ethers was encountered.The mechanistic features of the present electroreductive dechlorination are discussed.