1219805-31-8

Basic information

• Product Name: DL-HoMocysteine Thiolactone--d4 HCl
• Synonyms: DL-HoMocysteine Thiolactone--d4 HCl
• CAS NO: 1219805-31-8
• Molecular Formula: C₄H₇NOS*ClH
• Molecular Weight: 157.655067112
• Mol File: 1219805-31-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DL-HoMocysteine Thiolactone--d4 HCl(CAS DataBase Reference)
• NIST Chemistry Reference: DL-HoMocysteine Thiolactone--d4 HCl(1219805-31-8)
• EPA Substance Registry System: DL-HoMocysteine Thiolactone--d4 HCl(1219805-31-8)

Safety Data

• Hazardous Substances Data: 1219805-31-8(Hazardous Substances Data)

Usage

Uses

DL-Homocysteine Thiolactone-3,3,4,4-d4 HCl (CAS# 1219805-31-8) is a useful isotopically labeled research compound.

Upstream product

• 93709-61-6 DL-[3,3,4,4-⁽²⁾H₄]methionine 

Downstream Products

• 1242769-24-9 (3R,2'S)-3-(2'-methoxy-2'-phenyl)acetamido-4,4,5,5-tetradeutero-2-thiophenone 
• 1242769-23-8 (3S,2'S)-3-(2'-methoxy-2'-phenyl)acetamido-4,4,5,5-tetradeutero-2-thiophenone 

Relevant articles and documents

Synthesis of optically active deuterium-labeled homocysteine thiolactone

Optically pure (R)- and (S)-3-aminotetradeutero-2-thiophenone (D- and L-[2H4]homocysteine thiolactone) for use as substrates for metabolic and pharmacokinetic studies has been prepared. The racemic [ 2H4]homocysteine thiolactone hydrochloride was prepared from commercially available and highly enriched DL-[3,3,4,4-2H 4]methionine by intramolecular condensation with hydriodic acid. The racemate was derivatized with (S)-(+)-2-methoxyphenylacetic acid to form the diastereomeric amides. The diastereomers were separated by silica gel column chromatography. Hydrolysis of the D- and L-isomer amide in 4M HCl-ethanol (1:2 v/v) afforded the optically pure D- and L-[2H4] homocysteine thiolactone, respectively. Copyright