1219819-24-5

Basic information

• Product Name: 9-O-[2-(phenyloxy)ethyl]berberine bromide
• Synonyms: 9-O-[2-(phenyloxy)ethyl]berberine bromide
• CAS NO: 1219819-24-5
• Molecular Weight: 522.395
• Mol File: 1219819-24-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 9-O-[2-(phenyloxy)ethyl]berberine bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 9-O-[2-(phenyloxy)ethyl]berberine bromide(1219819-24-5)
• EPA Substance Registry System: 9-O-[2-(phenyloxy)ethyl]berberine bromide(1219819-24-5)

Safety Data

• Hazardous Substances Data: 1219819-24-5(Hazardous Substances Data)

Upstream product

• 15401-69-1 berberrubine chloride 
• 589-10-6 phenoxyethyl bromide 
• 108275-17-8 berberrubine 

Relevant articles and documents

Synthetic method of 9-O-substituted phenoxyl alkyl berberine derivative

The invention discloses a synthetic method of a 9-O-substituted phenoxyl alkyl berberine derivative. The method comprises the following steps: by taking tetrabutylammonium bromide as a phase transfercatalyst and DMF (Dimethyl Formamide) as a solvent, first, carrying out a reaction on alpha, omega-dibromo alkane and phenol to synthesize bromoalkyl phenyl ether; then carrying out a reaction directly with berberrubine at 80 DEG C for 4 hours; after reaction, pouring the mixture into ice water while being hot, cooling the mixture to separate out a solid; and then carrying out filtration and recrystallization of dichloromethane and absolute methanol (V/V=10: 1) to obtain a yellow powder solid which is 9-O-substituted phenoxyl alkyl berberine derivative. Compared with a conventional method of synthesizing the 9-O-substituted phenoxyl alkyl berberine derivative, the method has the advantages of being mild in reaction condition, high in efficiency, few in byproduct, short in time, simple to operate, good in color and luster of products, high in purity and the like, and has a relatively high actual application prospect.