121985-73-7Relevant academic research and scientific papers
Metal-Free Decarboxylative Trichlorination of Alkynyl Carboxylic Acids: Synthesis of Trichloromethyl Ketones
Jayaraman, Aravindan,Cho, Eunjeong,Irudayanathan, Francis Mariaraj,Kim, Jimin,Lee, Sunwoo
, p. 130 - 141 (2017/12/26)
2,2,2-Trichloroacetophenone derivatives were synthesized via decarboxylative trichlorination from arylpropiolic acids and trichloroisocyanuric acid (TCCA). The reaction was performed in the presence of water at room temperature, and the desired products were obtained in good yields. The reaction showed good functional group tolerance towards halide, cyano, nitro, ketone, ester and aldehyde groups. In addition, the 2,2,2-trichloroacetophenone derivatives were readily transformed into esters, amides, and hydrazides. Based on experiments with H218O (water-18O), we proposed a cationic reaction pathway as the mechanism and suggested two different pathways for producing aryl- and alkyl-substituted propiolic acids. (Figure presented.).
Reactions of Trichloromethyl Anions with Diformylbenzenes. Estimation of Hammett Substituent Constants of the Formyl, Trichloroacetyl, and 2,2,2-Trichloro-1-hydroxyethyl Groups
Wassef, Wasfy N.,Ghobrial, Nadia M.
, p. 251 - 254 (2007/10/02)
o- and p-diformylbenzenes react at room temperature with trichloroacetic acid in dimethyl sulphoxide to yield insoluble products corresponding to the addition of trichloromethyl anion to carbonyl groups.The addition of one -CCl3 ion to the o-is
