1219925-97-9Relevant academic research and scientific papers
A convenientmicrowave-enhanced solid-phase synthesis of short chain N-methyl-rich peptides
Rodriguez, Hortensia,Suarez, Margarita,Albericio, Fernando
, p. 136 - 140 (2010)
Structural modification of the peptide backbone via N-methylation is a powerful tool to modulate the pharmacokinetic profile and biological activity of peptides. Here we describe a rapid and highly efficient microwave(MW)-assisted Fmoc/tBu solid-phase methodto prepare short chain N-methyl-rich peptides, using Rink amide p-methylbenzhydrylamine (MBHA) resin as solid-phase support. This method produces peptides in high yield and purity, and reduces the time required for Fmoc-N-methyl amino acid coupling. Copyright
