1219937-97-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Amino-5-methoxy-4-(3-morpholinopropoxy)phenyl)ethanone is used as a potential therapeutic agent for neurological disorders due to its inhibitory effects on the enzyme glycogen synthase kinase 3 (GSK-3). The inhibition of GSK-3 is believed to have beneficial effects on the treatment of Alzheimer's disease and bipolar disorder, as it may help regulate the production of amyloid precursor protein and tau protein, which are associated with the pathogenesis of these conditions.
Used in Research and Development:
1-(2-Amino-5-methoxy-4-(3-morpholinopropoxy)phenyl)ethanone is used as a research compound for studying the role of GSK-3 in neurological disorders and exploring its potential as a drug candidate. Preclinical studies have shown its promise in treating Alzheimer's disease and bipolar disorder, and ongoing research aims to further understand its mechanism of action and optimize its therapeutic potential.
Used in Drug Discovery and Design:
1-(2-Amino-5-methoxy-4-(3-morpholinopropoxy)phenyl)ethanone serves as a lead compound in the development of new drugs targeting GSK-3. Its unique chemical structure and inhibitory properties make it a valuable starting point for the design of more potent and selective GSK-3 inhibitors, which could lead to the development of novel treatments for neurological disorders.

Upstream product

• 1184831-17-1 1-[5-methoxy-4-(3-bromo-propoxy)-2-nitro-phenyl]-ethanone 
• 1219937-96-8 1-[5-methoxy-4-(3-morpholin-4-yl-propoxy)-2-nitro-phenyl]-ethanone 

Downstream Products

• 205448-32-4 4-chloro-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline 
• 960299-44-9 4-(3-((4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yl)oxy)propyl)morpholine 
• 479690-10-3 3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline 
• 849221-53-0 cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide 
• 1167053-13-5 6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ol, sodium salt 

Relevant academic research and scientific papers

PROCESS FOR PREPARING QUINOLINE DERIVATIVES

A process for preparing a compound of Formula I is disclosed, comprising the steps: wherein: R1 is halo; R2 is halo; R3 is (C1-C6)alkyl or (C1-C6)alkyl optionally substituted wit

Preparation of a Quinolinyloxydiphenylcyclopropanedicarboxamide

The present invention relates to a process of preparing a compound of the following formula III: wherein R1-R4 are as defined herein. The present invention also relates to the preparation of intermediates used to prepare the compound

METHODS OF PREPARING QUINOLINE DERIVATIVES

A Method of preparing a compound of formula i(1) or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 join together with the nitrogen atom to which they are attached form a 6 membered heterocycloalkyl X1 is H,

METHODS OF PREPARING QUINOLINE DERIVATIVES

Methods of preparing compounds of formula i(1): or a pharmaceutically acceptable salt R1 and R2 join together with the nitrogen atom to which they are attached to form a 6 membered heterocycloalkyl group; X1 is H, Br, Cl o