121996-22-3Relevant academic research and scientific papers
POTENTIAL ANTIDEPRESSANTS: 2-(6,11-DIHYDRODIBENZOTHIEPIN-11-YL)-4,5-DIHYDROIMIDAZOLES
Sindelar, Karel,Metysova, Jirina,Protiva, Miroslav
, p. 229 - 234 (2007/10/02)
Reactions of 2-substituted 11-chloro-6,11-dihydrodibenzothiepins with trimethylsilyl cyanide in dichloromethane in the presence of stannic chloride afforded nitriles IIb-IId in high yields.Heating of IIa-IId with 2-aminoethylammonium toluene-4-sulfonate to 200 deg C gave the title compounds Ia-Id which were transformed to hydrogen maleates.Compound Ic (hydrogen maleate VUFB-17092) showed in several tests a clear thymoleptic (potential antidepressant) character.
