1219961-89-3Relevant academic research and scientific papers
Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists
Budzik, Brian W.,Evans, Karen A.,Wisnoski, David D.,Jin, Jian,Rivero, Ralph A.,Szewczyk, George R.,Jayawickreme, Channa,Moncol, David L.,Yu, Hongshi
supporting information; experimental part, p. 1363 - 1367 (2010/07/10)
A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening campaign as novel, potent agonists of the human TGR5 G-protein-coupled receptor is described. Many analogues were readily accessible via solution-phase synthesis which
