1219977-99-7Relevant academic research and scientific papers
Ruthenium-catalyzed C-H activation/cyclization for the synthesis of phosphaisocoumarins
Park, Youngchul,Jeon, Incheol,Shin, Seohyun,Min, Jiae,Lee, Phil Ho
, p. 10209 - 10220 (2013/11/06)
An efficient and cost-effective ruthenium-catalyzed oxidative cyclization of phosphonic acid monoesters or phosphinic acids with alkynes has been developed for the synthesis of a wide range of phosphaisocoumarins in good to excellent yields under aerobic conditions. A multitude of arylphosphonic acid monoesters and arylphosphinic acids having electron-donating and -withdrawing groups were oxidatively cyclized. Various diarylacetylenes, dialkylacetylenes, and alkylarylacetylenes effectively underwent the ruthenium-catalyzed oxidative cyclization. A substrate possessing benzoic acid as well as a phenylphosphonic monoester moiety was smoothly cyclized with hex-3-yne to afford a compound having both isocoumarin and phosphaisocoumarin moieties. Alkenylphosphonic monoester afforded phosphorus 2-pyrone through oxidative cyclization with alkyne. Competition experiments between diaryl- and dialkylalkynes and between diarylacetylenes having p-methoxy and p-chloro groups gave results which showed that the present oxidative cyclizations were not affected by the electronic effects of alkynes. Mechanistic studies revealed C-H bond metalation to be the rate-limiting step.
