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1219978-22-9

Based on the provided literature abstracts, **1-((4-fluorophenyl)-(piperidin-1-yl)-methyl)naphthalen-2-ol** is a Mannich base derivative synthesized via a three-component reaction involving 2-naphthol, a 4-fluorobenzaldehyde, and piperidine. Such compounds are typically formed through Betti or Mannich reactions and may exhibit biological activity, including antibacterial properties, particularly when derived from secondary amines like piperidine. However, no specific data on this exact compound's properties or applications are detailed in the given abstracts. **Returned paragraph:** 1-((4-Fluorophenyl)-(piperidin-1-yl)-methyl)naphthalen-2-ol is a Mannich base derivative synthesized from 2-naphthol, 4-fluorobenzaldehyde, and piperidine. Such compounds are often explored for potential antibacterial activity, though specific data on this particular derivative is not provided in the reviewed literature.

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  • 1-((4-fluorophenyl)-(piperidin-1-yl)-methyl)naphthalen-2-ol

    Cas No: 1219978-22-9

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  • 1219978-22-9 Structure

  • Basic information

    1. Product Name: 1-((4-fluorophenyl)-(piperidin-1-yl)-methyl)naphthalen-2-ol
    2. Synonyms: 1-((4-fluorophenyl)-(piperidin-1-yl)-methyl)naphthalen-2-ol
    3. CAS NO:1219978-22-9
    4. Molecular Formula:
    5. Molecular Weight: 335.421
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1219978-22-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-((4-fluorophenyl)-(piperidin-1-yl)-methyl)naphthalen-2-ol(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-((4-fluorophenyl)-(piperidin-1-yl)-methyl)naphthalen-2-ol(1219978-22-9)
    11. EPA Substance Registry System: 1-((4-fluorophenyl)-(piperidin-1-yl)-methyl)naphthalen-2-ol(1219978-22-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1219978-22-9(Hazardous Substances Data)

1219978-22-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1219978-22-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,9,9,7 and 8 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1219978-22:
(9*1)+(8*2)+(7*1)+(6*9)+(5*9)+(4*7)+(3*8)+(2*2)+(1*2)=189
189 % 10 = 9
So 1219978-22-9 is a valid CAS Registry Number.

1219978-22-9Downstream Products

1219978-22-9Relevant articles and documents

Nanocrystalline TiO2-HClO4 catalyzed three-component preparation of derivatives of 1-amidoalkyl-2-naphthol, 1-carbamato-alkyl-2- naphthol, 1-(α-aminoalkyl)-2-naphthol, and 12-aryl-8,9,10,12- tetrahydrobenzo[a]-xanthen-11-one

Shaterian, Hamid Reza,Mohammadnia, Majid

, p. 4221 - 4237 (2013)

1-Amidoalkyl-2-naphthols, 1-carbamatoalkyl-2-naphthols, and 1-(α-aminoalkyl)-2-naphthols have been prepared by three-component reaction of 2-naphthol, aromatic aldehydes, and NH compounds, i.e. amides, carbamates, and secondary amines, respectively, in th

Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines

Roman, Gheorghe,Nǎstasǎ, Valentin,Bostǎnaru, Andra-Cristina,Mare?, Mihai

, p. 2498 - 2502 (2016)

A small library of 1-aminoalkyl 2-naphthols has been synthesized through the direct Mannich reaction of 2-naphthols with (hetero)aromatic aldehydes and secondary amines. All of the Mannich bases having a thiophen-2-yl ring in their structure had good acti

Magnetic nanocrystallites strontium hexaferrite as an efficient catalyst in the green Betti reaction

Mohammadi Ziarani, Ghodsi,Kazemi Asl, Zhila,Gholamzadeh, Parisa,Badiei, Alireza,Afshar, Morteza

, p. 515 - 520 (2018)

The sol–gel auto-combustion method was applied for preparation of SrFe12O19 magnetic nanoparticles (MNPs). Then, the prepared SrFe12O19 was analyzed by VSM, FT-IR, SEM, N2 adsorption-desorption and XR

Synthesis of 1-aminoalkyl-2-naphthols derivatives using an engineered copper-based nanomagnetic catalyst (Fe3O4@CQD@Si (OEt)(CH2)3NH@CC@N3@phenylacetylene@Cu)

Akbarpour, Tahereh,Khazaei, Ardeshir,Sarmasti, Negin,Yousefi Seyf, Jaber

, (2021/07/26)

In the present study, a molecular level engineered-based method was used to synthesis a copper-based nanomagnetic catalyst (Fe3O4@CQD@Si (OEt)(CH2)3NH@CC@N3@phenylacetylene@Cu). The as-synthesized cat

Solventless synthesis of 1-(α-aminoalkyl) naphthols, betti bases, catalyzed by nanoparticle Fe3O4 at room temperature

Janati, Fatemeh,Heravi, Majid M.,Shokraie, Ahmad Mir

, p. 1 - 5 (2014/11/07)

A series of 1-(a-aminoalkyl) naphthols were synthesized expeditiously in good yields and selectivity from 2-naphthol, alkylamines and aldehydes in the presence of nanoparticle fe3o4 at room temperature in solvent-free conditions. Taylor & Francis Group, LLC.

Non-ionic surfactant catalyzed synthesis of Betti base in water

Kumar, Atul,Gupta, Maneesh Kumar,Kumar, Mukesh

supporting information; experimental part, p. 1582 - 1584 (2010/06/13)

We have developed an efficient non-ionic surfactant (Triton X-100) catalyzed multicomponent synthesis of Betti base from secondary amine, aromatic aldehydes, and β-naphthol using Mannich-type reaction in water. Lewis and Br?nsted acid catalysts, ionic and non-ionic surfactant have been screened for the reaction. Non-ionic surfactant (Triton X-100) gave the best results and the reaction proceeds through the imine formation, which is stabilized by colloidal dispersion and undergoes nucleophilic addition to afford the corresponding N,N-dialkylated Betti base in excellent yields.

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