1219979-21-1 Usage
General Description
N-(3-Azetidinyl)benzamide is a chemical compound with the molecular formula C11H12N2O. It is a benzamide derivative that contains a five-membered azetidine ring. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds, particularly in the development of potential drug candidates. N-(3-Azetidinyl)benzamide has been studied for its potential anti-inflammatory and analgesic properties, and has shown promise in preclinical research. Its unique structure and functional groups make it a valuable tool for medicinal chemists in the rational design and synthesis of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1219979-21-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,9,9,7 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1219979-21:
(9*1)+(8*2)+(7*1)+(6*9)+(5*9)+(4*7)+(3*9)+(2*2)+(1*1)=191
191 % 10 = 1
So 1219979-21-1 is a valid CAS Registry Number.
1219979-21-1Relevant articles and documents
The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL)
Chevalier, Kristen M.,Connolly, Peter J.,Flores, Christopher M.,Macielag, Mark J.,Milligan, Cynthia M.,Zhang, Sui-Po,Zhu, Bin
, (2020/04/27)
Monoacylglycerol lipase (MAGL) has emerged as an attractive drug target because of its important role in regulating the endocannabinoid 2-arachidonoylglycerol (2-AG) and its hydrolysis product arachidonic acid (AA) in the brain. Herein, we report the discovery of a novel series of diazetidinyl diamide compounds 6 and 10 as potent reversible MAGL inhibitors. In addition to demonstrating potent MAGL inhibitory activity in the enzyme assay, the thiazole substituted diazetidinyl diamides 6d–l and compounds 10 were also effective at increasing 2-AG levels in a brain 2-AG accumulation assay in homogenized rat brain. Furthermore, selected compounds have been shown to achieve good brain penetration after oral administration in an animal study.
