122003-39-8

Upstream product

• 122005-20-3 6-acetoxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid 
• 62-53-3 aniline 
• 146427-57-8 N-Phenyl-(6-acetoxy-3,4-dihydro-2,5,7,8-tetramethyl-2H[1]-benzopyran-2-yl)carboxamide 
• 56305-04-5 trolox 

Relevant academic research and scientific papers

Synthesis and anti-inflammatory activity of N-(aza)arylcarboxamides derived from Trolox

A series of 6-(aza)arylmethoxychroman-2-carboxamides 22-38, derived from Trolox or 6-hydroxy-2,5,7,8-tetra-methylchroman-2-carboxylic acid, was prepared using two strategies, i.e. phenol blockade was carried out before or after amidification. These compounds were evaluated against peripheral inflammation by a carrageenin-induced foot-pad edema test. A permanent blockade of the phenol function by arylmethoxy groupings, in particular by the quinolylmethoxy moiety, was generally detrimental to activity; only the 6-benzyloxy and quinolylmethoxy derivatives 22 and 31 exhibited significant inhibition (58.3 and 97.1%) after oral administration of 0.4 mrnol kg-1. Among their 6-acetoxy or 6-hydroxy precursors 12-21. evaluated at 0.4 and 0.1 mmol kg-1, the N-(4-pyridyl) chromancarboxamides 15 and 20 exerted the highest inhibitory activity. Their ID50 were 14.7 ± 5.5 mg kg-1 and 14.7 ± 4.5 mg kg-1, respectively. Elsevier, Paris.

Benzopyran compounds

A compound selected from the group consisting of those of formula I STR1 in which R1, R2, R3, R4, R5, R6, R7, X and n are defined in the description, an optical isomer thereof, and an addition salt thereof with a pharmaceutically-acceptable base or acid. Medicinal product which is useful in treating or in preventing a disorder due to or linked to the phenomena of peroxidation and to the disturbance of the eicosanoid biosynthesis.