122004-89-1Relevant academic research and scientific papers
Chemoselective deoxygenation of ether-substituted alcohols and carbonyl compounds by B(C6F5)3-catalyzed reduction with (HMe2SiCH2)2
Yang, Wenyu,Gao, Lu,Lu, Ji,Song, Zhenlei
supporting information, p. 4834 - 4837 (2018/05/23)
B(C6F5)3-catalyzed deoxygenation of ether-substituted alcohols and carbonyl compounds has been developed using (HMe2SiCH2)2 as the reductant. This unique reagent shows distinct superiority over traditional one silicon-centered hydrosilanes, giving the corresponding alkanes in high yields with good tolerance of ethers, aryl halides and alkenes. The control experiments suggest that (HMe2SiCH2)2 might facilitate the approach in an intramolecular Si/O activation manner.
Reactive two-component monolayers template bottom-up assembly of nanoparticle arrays on HOPG
Fang, Chen,Zhu, Hua,Chen, Ou,Zimmt, Matthew B.
supporting information, p. 8056 - 8059 (2018/07/29)
Two triphenyleneethynylene derivatives, 1OH and 2, self-assemble a patterned monolayer (ML) at the solution-graphite (HOPG) interface. The four molecule unit cell of the ML, (1OH1OH22), spans 19 nm and contains adjacent columns of 1OH molecules spaced by 4.7 nm. Following ML assembly, a disulfide is appended to the alcohol group on each 1OH molecule and used to capture 2.0 nm gold nanoparticles (AuNP). The patterned monolayer directs bottom-up assembly of a 5 nm/19 nm double pitch AuNP pattern.
Design, synthesis, and biological evaluation of N-Alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection
Yu, Wenquan,Gill, Tina,Wang, Lijuan,Du, Yanming,Ye, Hong,Qu, Xiaowang,Guo, Ju-Tao,Cuconati, Andrea,Zhao, Kang,Block, Timothy M.,Xu, Xiaodong,Chang, Jinhong
supporting information; experimental part, p. 6061 - 6075 (2012/08/14)
We recently described the discovery of oxygenated N-alkyl deoxynojirimycin (DNJ) derivative 7 (CM-10-18) with antiviral activity against dengue virus (DENV) infection both in vitro and in vivo. This imino sugar was promising but had an EC50 against DENV in BHK cells of 6.5 μM, which limited its use in in vivo. Compound 7 presented structural opportunities for activity relationship analysis, which we exploited and report here. These structure-activity relationship studies led to analogues 2h, 2l, 3j, 3l, 3v, and 4b-4c with nanomolar antiviral activity (EC50 = 0.3-0.5 μM) against DENV infection, while maintaining low cytotoxicity (CC50 > 500 μM, SI > 1000). In male Sprague-Dawley rats, compound 3l was well tolerated at a dose up to 200 mg/kg and displayed desirable PK profiles, with significantly improved bioavailability (F = 92 α 4%).
Pharmaceutically active amines
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, (2008/06/13)
The aromatic amines (I), alkyl amines (II), bicyclic amines (III). STR1 cycloalkyl amines (IV), aromatic bicyclic amines (V), hydroquinone amines (VI), quinone amines (VII), amino-ethers (VIII) and bicyclic amino ethers (IX) are useful as pharmaceutical agents for treating a number of conditions including spinal trauma, mild and/or moderate to severe head injury, etc. Also disclosed is a method of treatment using the 3,4-dihydrobenzopyrans (XI).
