122004-95-9

Upstream product

• 13037-83-7 4-allyl-2,6-dimethylphenol 
• 576-26-1 2.6-dimethylphenol 
• 107-18-6 allyl alcohol 
• 540778-59-4 ethyl (2E)-3-(4-hydroxy-3,5-dimethylphenyl)2-propenoate 
• 2233-18-3 4-hydroxy-3,5-dimethylbenzaldehyde 

Downstream Products

• 122004-94-8 3-(3,5-dimethyl-4-hydroxyphenyl)propanol bismesylate 
• 1005515-82-1 1-bromo-3-(3,5-dimethyl-4-hydroxyphenyl)propane 
• 138345-02-5 7,9-dimethyl-1-oxaspiro<4.5>deca-6,9-dien-8-one 
• 138345-03-6 1-methoxy-1-(3,5-dimethyl-4-hydroxyphenyl)propanol 
• 527-61-7 2,6-dimethyl-1,4-benzoquinone 

Relevant academic research and scientific papers

Phenyl trimethyl ammonium tribromide mediated robust one-pot synthesis of spiro-oxacycles-an economic route-stereoselective synthesis of oxaspirohexacyclodieneones

This paper entails the first recognition of Phenyl Trimethyl Ammonium Tribromide (PTAB) as an effective reagent for spiro-cyclizations proceeding via oxidative dearomatization. The experiment exhibits economical, metal and ligand free one-pot accomplishment of these significant transformations. The described protocol presents the first generalised methodology of spiro-oxacycle synthesis which can be applied towards various directions. A stereoselective synthesis of oxa-spirocyclooxadieneones has been accomplished.

γ-hydroxypropylation of 2,6-dialkyl(aryl)phenols with allyl alcohol and its derivatives

The composition of the products of the reaction of 2,6-disubstituted phenols with allyl alcohol and its derivatives in an alkaline medium was investigated, the conditions for carrying out the reaction with the predominant formation of 4-(3-hydroxypropyl)-2,6-dialkyl(aryl)phenols were found, and its mechanism was suggested. The reaction was examined on an industrial scale. An important result is the practical demonstration of alkaline catalysis performed under homogeneous conditions with participation of phenols, when the used alkaline catalyst is recovered in the process without the formation of waste waters. Pleiades Publishing, Ltd., 2010.

New promising antioxidants based on 2,6-dimethylphenol

Three new sulfur-containing derivatives of 2,6-dimethylphenol were synthesized. Their antioxidative activity, mutagenicity, and genotoxicity were examined by bacterial tests and by calculating the dominant lethal mutations in murine embryonic cells. It was shown that all the compounds synthesized have a marked antioxidative effect and have no genotoxic and mutagenic properties. One of the antioxidants, 4-(3-dodecylthiopropyl)-2,6-dimethylphenol, increases the survival of cells of both the wild-type Escherichia coli strain and bacterial strains defective in the genes of repair enzymes and has a more distinct antioxidative effect than the classic antioxidants α-tocopherol and trolox, increasing the survival of cells devoid of repair enzymes.

Synthesis and antioxidant properties of sodium S-[3-(hydroxyaryl)propyl] thiosulfates and [3-(hydroxyaryl)propane]-1-sulfonates

Sodium S-[3-(hydroxyaryl)propyl] thiosulfates and [3-(hydroxyaryl)propane]- 1-sulfonates with various spatial hindrance of their phenolic OH groups were synthesized from dialkylphenols via a number of intermediate products. On a model reaction of oxidation of methyl oleate in aqueous sodium dodecyl sulfate, the rate constants of the interaction of the synthesized compounds with lipoperoxide radicals were determined.

Pharmaceutically active amines

The aromatic amines (I), alkyl amines (II), bicyclic amines (III). STR1 cycloalkyl amines (IV), aromatic bicyclic amines (V), hydroquinone amines (VI), quinone amines (VII), amino-ethers (VIII) and bicyclic amino ethers (IX) are useful as pharmaceutical agents for treating a number of conditions including spinal trauma, mild and/or moderate to severe head injury, etc. Also disclosed is a method of treatment using the 3,4-dihydrobenzopyrans (XI).