1220095-44-2Relevant academic research and scientific papers
Potent glucosidase inhibitors: De-o-suifonated ponkoranol and its stereoisomer
Eskandari, Razieh,Kuntz, Douglas A.,Rose, David R.,Mario Pinto
supporting information; experimental part, p. 1632 - 1635 (2010/06/19)
(Figure Presented) Ponkoranol, a glucosidase inhibitor isolated from the plant Salacia reticulata, comprises a sulfonium ion with an internal sulfate counterion. An efficient synthetic route to de-O-sulfonated ponkoranol and its 5'-stereoisomer is reported, and it is shown that these compounds are potent glucosidase inhibitors that inhibit a key intestinal human glucosidase, the N-terminal catalytic domain of maltase glucoamylase, with K, values of 43 ± 3 and 15 ± 1 nM, respectively.
