1220165-54-7

Basic information

• Product Name: 4-broMo-1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine
• Synonyms: 4-broMo-1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine;2,1-Benzoxaborole, 1,3-dihydro-1-hydroxy-3,3-diMethyl;4-bromo-1-(4-fluorophenyl)pyrazolo[3,4-c]pyridine
• CAS NO: 1220165-54-7
• Molecular Formula: C₁₂H₇BrFN₃
• Molecular Weight: 292.1064832
• Mol File: 1220165-54-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 334.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.66±0.1 g/cm3(Predicted)
• PKA: 3.86±0.30(Predicted)
• CAS DataBase Reference: 4-broMo-1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine(1220165-54-7)
• EPA Substance Registry System: 4-broMo-1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine(1220165-54-7)

Safety Data

• Hazardous Substances Data: 1220165-54-7(Hazardous Substances Data)

Usage

General Description

4-bromo-1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine is a chemical compound with the molecular formula C14H8BrFN3. It is a heterocyclic compound that belongs to the pyridine family and contains a pyrazole ring. 4-broMo-1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine is primarily used in pharmaceutical research as it has potential applications in drug development. Its structure and properties make it a valuable building block for the synthesis of various biologically active molecules. Additionally, it is also being studied for its potential therapeutic effects in the treatment of various diseases and conditions. As a result, it is of significant interest to researchers in the pharmaceutical and chemical industries.

Upstream product

• 70201-42-2 3,5-dibromopyridine-4-carboxaldehyde 
• 371-14-2 4-fluorophenylhydrazine 
• 1220165-45-6 N-[1-(3,5-dibromopyridin-4-yl)-meth-(E)-ylidene]-N'-(4-fluorophenyl)-hydrazine 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 

Downstream Products

• 1220025-85-3 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide 
• 1220165-87-6 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid ethyl ester 
• 1220026-26-5 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide 
• 1345828-31-0 1-(4-fluoro-phenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (5-methanesulfonyl-2,4-dimethyl-phenyl)-amide 
• 1295298-15-5 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-bromophenyl)cyclopropyl]amide 
• 1295298-14-4 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (1-1,3,4-thiadiazol-2-yl-cyclopropyl)amide 
• 1295298-11-1 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(2-bromopyridin-4-yl)cyclopropyl]amide 
• 1295298-09-7 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(5-methanesulfonyl-furan-2-yl)cyclopropyl]amide 
• 1295298-36-0 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(3-trifluoromethyl-phenyl)cyclopropyl]amide 

Relevant articles and documents

Identification of novel azaindazole CCR1 antagonist clinical candidates

Exploring various cyclization strategies, using a submicromolar pyrazole HTS screening hit 6 as a starting point, a novel indazole based CCR1 antagonist core was discovered. This report presents the design and SAR of CCR1 indazole and azaindazole antagonists leading to the identification of three development compounds, including 19e that was advanced to early clinical trials.

AZAINDAZOLE AMIDE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS

Disclosed are CCR1 inhibitor compounds of the formula (I): which are useful in the treatment of autoimmune and other diseases. Also disclosed a pharmaceutical compositions containing the same, and methods of making and using same.