Prepro-thyrotropin releasing hormone (160-169) is a peptide chain that serves as a precursor to the hormone thyrotropin releasing hormone (TRH). It is derived from the prepro-TRH protein, which undergoes processing and cleavage to yield the active TRH hormone. TRH plays a crucial role in the regulation of the thyroid gland and the release of thyroid-stimulating hormone (TSH) from the pituitary gland. This peptide chain is significant for its potential therapeutic applications in the treatment of thyroid disorders and other related conditions. Further research into prepro-TRH and its derivatives may yield insights into novel treatments for endocrine disorders and other health conditions.
122018-91-1
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Basic information
- Product Name: prepro-thyrotropin releasing hormone (160-169)
- Synonyms: L-Threonine,N-[N-[N-[N-[N-[N-[N-[1-(N-L-seryl-L-phenylalanyl)-L-prolyl]-L-tryptophyl]-L-methionyl]-L-a-glutamyl]-L-seryl]-L-a-aspartyl]-L-valyl]-; 173: PN:US20090175821 SEQID: 214 claimed protein; 35: PN: WO0069900 SEQID: 214unclaimed sequence; Ps 4; TRH-potentiating peptide; TRH-potentiating peptide(ox)
- CAS NO:122018-91-1
- Molecular Formula: C54H75N11O18S
- Molecular Weight: 1198.31
- EINECS: N/A
- Product Categories: N/A
- Mol File: 122018-91-1.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 1696.2°C at 760 mmHg
- Flash Point: 979.6°C
- Appearance: /
- Density: 1.404g/cm3
- Vapor Pressure: 0mmHg at 25°C
- Refractive Index: 1.619
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: prepro-thyrotropin releasing hormone (160-169)(CAS DataBase Reference)
- NIST Chemistry Reference: prepro-thyrotropin releasing hormone (160-169)(122018-91-1)
- EPA Substance Registry System: prepro-thyrotropin releasing hormone (160-169)(122018-91-1)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 122018-91-1(Hazardous Substances Data)
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122018-91-1 Usage
Uses
Used in Pharmaceutical Industry:Prepro-thyrotropin releasing hormone (160-169) is used as a therapeutic agent for the treatment of thyroid disorders. Its role in the regulation of the thyroid gland and the release of TSH makes it a promising candidate for managing conditions related to thyroid dysfunction.
Used in Research and Development:
In the field of endocrine research, prepro-thyrotropin releasing hormone (160-169) is used as a subject of study to explore novel treatments for endocrine disorders. Its potential applications extend beyond thyroid-related conditions, as further investigation may reveal its impact on other health conditions influenced by the endocrine system.
Used in Diagnostic Tools:
Prepro-thyrotropin releasing hormone (160-169) may also be utilized in the development of diagnostic tools to assess thyroid function and monitor the effectiveness of treatments for thyroid disorders. Its presence and levels could serve as biomarkers for certain conditions, aiding in early detection and intervention.
Check Digit Verification of cas no
The CAS Registry Mumber 122018-91-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,0,1 and 8 respectively; the second part has 2 digits, 9 and 1 respectively.Calculate Digit Verification of CAS Registry Number 122018-91:
(8*1)+(7*2)+(6*2)+(5*0)+(4*1)+(3*8)+(2*9)+(1*1)=81
81 % 10 = 1
So 122018-91-1 is a valid CAS Registry Number.
InChI:InChI=1/C54H75N11O18S/c1-27(2)43(52(80)64-44(28(3)68)54(82)83)63-49(77)37(23-42(71)72)59-50(78)39(26-67)62-46(74)34(16-17-41(69)70)57-47(75)35(18-20-84-4)58-48(76)36(22-30-24-56-33-14-9-8-13-31(30)33)60-51(79)40-15-10-19-65(40)53(81)38(61-45(73)32(55)25-66)21-29-11-6-5-7-12-29/h5-9,11-14,24,27-28,32,34-40,43-44,56,66-68H,10,15-23,25-26,55H2,1-4H3,(H,57,75)(H,58,76)(H,59,78)(H,60,79)(H,61,73)(H,62,74)(H,63,77)(H,64,80)(H,69,70)(H,71,72)(H,82,83)/t28-,32+,34+,35+,36+,37+,38+,39+,40+,43+,44+/m1/s1
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prepro-thyrotropin releasing hormone (160-169)
