122023-29-4

Basic information

• Product Name: 2'-FLUORO-4'-(TRIFLUOROMETHYL)ACETOPHENONE
• Synonyms: 1-[2-Fluoro-4-(trifluoromethyl)phenyl]ethanone;2'-FLUORO-4'-(TRIFLUOROMETHYL)ACETOPHENONE;2-FLUORO-4-(TRIFLUOROMETHYL)ACETOPHENONE;2'-Fluoro-4'-(trifluoromethyl)acetophenone, 97+%;2'-Fluoro-4'-(trifluoromethyl)acetophenone 98%;2'-Fluoro-4'-(trifluoromethyl)acetophenone98%;2'-Fluoro-4'-(trifluoromethyl)acetophenone;1-[2-Fluoro-4-(trifluoromethyl)phenyl]ethan-1-one, 4-Acetyl-3-fluorobenzotrifluoride
• CAS NO: 122023-29-4
• Molecular Formula: C₉H₆F₄O
• Molecular Weight: 206.14
• Mol File: 122023-29-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 207°Cat760mmHg
• Flash Point: 77.3°C
• Appearance: /
• Density: 1.299g/cm³
• Vapor Pressure: 0.23mmHg at 25°C
• Refractive Index: 1.446
• CAS DataBase Reference: 2'-FLUORO-4'-(TRIFLUOROMETHYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-FLUORO-4'-(TRIFLUOROMETHYL)ACETOPHENONE(122023-29-4)
• EPA Substance Registry System: 2'-FLUORO-4'-(TRIFLUOROMETHYL)ACETOPHENONE(122023-29-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 122023-29-4(Hazardous Substances Data)

Usage

General Description

2'-Fluoro-4'-(trifluoromethyl)acetophenone is a chemical compound with the molecular formula C10H7F4O. It is a fluorinated aromatic ketone with a methyl group bonded to the carbon atom adjacent to the carbonyl group. The trifluoromethyl group is attached to the aromatic ring at the 4' position. 2'-FLUORO-4'-(TRIFLUOROMETHYL)ACETOPHENONE is often used as a building block for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure and properties make it a valuable intermediate in organic synthesis, particularly in the development of fluorinated molecules with potential applications in various fields such as medicine and materials science.

InChI:InChI=1/C9H6F4O/c1-5(14)7-3-2-6(4-8(7)10)9(11,12)13/h2-4H,1H3

Upstream product

• 89763-93-9 2-Fluoro-4-(trifluoromethyl)benzaldehyde 

Downstream Products

• 537050-12-7 2-bromo-1-(2-fluoro-4-trifluoromethylphenyl)ethanone 
• 1146011-20-2 6-trifluoromethyl-3-methylindazole 

Relevant articles and documents

Method for synthesizing 6-trifluoromethyl-3-methylindazole

The invention relates to the field of synthesis of indazole compounds, and discloses a method for synthesizing 6-trifluoromethyl-3-methylindazole, which comprises the following steps: a, dissolving a raw material 2-fluoro-4-trifluoromethylbenzaldehyde in an organic solvent, cooling to -15 to -20 DEG C under the protection of argon, dropwise adding a methylmagnesium chloride solution, to prepare 1-(2-fluoro-4-trifluoromethyl phenyl) ethanol; b, dissolving 1-(2-fluoro-4-trifluoromethyl phenyl) ethanol in dichloromethane, adding PCC for a reaction at the room temperature, performing filtering and concentration, dissolving out a product through a mixed solution of ethyl acetate and petroleum ether, performing filtering and concentration, and obtaining 2-fluoro-4-trifluoromethyl acetophenone; and c, dissolving 2-fluoro-4-trifluoromethyl acetophenone in an organic solvent, adding hydrazine hydrate, reacting at 90-100 DEG C, concentrating the reaction solution, pulping with the organic solvent, carrying out suction filtration, and drying to obtain the product. The method solves the problem that an effective method for synthesizing the 6-trifluoromethyl-3-methylindazole is lacked in the prior art, and is short in synthesis route and simple and convenient to operate.