1220283-60-2Relevant academic research and scientific papers
Use of aryl chlorides as electrophiles in Pd-catalyzed alkene difunctionalization reactions
Rosen, Brandon R.,Ney, Joshua E.,Wolfe, John P.
, p. 2756 - 2759 (2010)
The development of conditions that allow use of inexpensive aryl chlorides as electrophiles in Pd-catalyzed alkene carboamination and carboetherification reactions is described. A catalyst composed of Pd(OAc)2 and S-Phos minimizes N-arylation of the substrate and prevents formation of mixtures of regioisomeric products. A number of heterocycles, including pyrrolidines, isoxazolidines, tetrahydrofurans, and pyrazolidines, are efficiently generated with this method.
