1220357-26-5Relevant academic research and scientific papers
Synthesis, crystal structures and photoluminescence of 7-(N,N′-diethylamino)-3-phenylcoumarin derivatives
Yu, Tianzhi,Meng, Jing,Zhang, Peng,Zhao, Yuling,Zhang, Hui,Fan, Duowang,Chen, Lili,Qiu, Yongqing
, (2010)
Two new coumarin derivatives, 7-(N,N′-diethylamino)-3-(4-hydroxyphenyl)-coumarin and 7-(N,N′-diethylamino)-3-(4-bromophenyl)-coumarin, were synthesized successfully. Their structures were verified by single crystal X-ray crystallography. The UV-vis absorp
Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents
Hu, Yuheng,Wang, Bing,Yang, Jie,Liu, Teng,Sun, Jie,Wang, Xiaojing
, p. 15 - 30 (2018/10/31)
A variety of substituted 3-arylcoumarin derivatives were synthesised through microwave radiation heating. The method has characteristics of environmental friendliness, economy, simple separation, and purification process, less by-products and high reaction yield. Those 3-arylcoumarin derivatives were screened for antioxidant, α-glucosidase inhibitory and advanced glycation end-products (AGEs) formation inhibitory. Most compounds exhibited significant antioxidant and AGEs formation inhibitory activities. Anti-diabetic activity studies showed that compounds 11 and 17 were equipotent to the standard drug glibenclamide in vivo. According to the experimental results, the target compound 35 can be used as a lead compound for the development of new anti-diabetic drugs. The whole experiment showed that anti-diabetic activity is prevalent in 3-arylcoumarins, which added a new natural skeleton to the development of anti-diabetic active drugs.
MANUFACTURING METHOD OF COUMARIN DERIVATIVE, MANUFACTURING METHOD OF FLUORESCENT AGENT FOR COLORING AND MANUFACTURING METHOD OF DYE FOR FLUORESCENCE
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Paragraph 0056, (2017/10/11)
PROBLEM TO BE SOLVED: To provide an easier, low cost and high yield manufacturing method of 3-aryl-7-N,N-dialkyl aminocoumarin derivative. SOLUTION: There is provided a manufacturing method of 3-aryl-7-dialkyl aminocoumarin derivative represented by the formula (3) by reacting acrylic acids having a 4-amino-2-carboxy-phenyl group and further a phenyl group, dialkyl sulfate compound, Lewis acid at same time or in sequence in a same bath. (3), where Ar is a phenyl group, a thienyl group, a pyridyl group or a naphthyl group which may have a substituent, R3 is a C1 to 4 linear/branched alkyl group, R4 is H, C1 to 8 linear/branched alkyl group, benzyl group or the like. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
