122039-33-2Relevant academic research and scientific papers
Synthesis of a Difluoromethylenephosphonate Analogue of Glycerol-3-phosphate. A Substrate for NADH Linked Glycerol-3-phosphate Dehydrogenase
Chambers, Richard D.,Jaouhari, Rabih,O'Hagan, David
, p. 1169 - 1170 (1988)
A synthesis of the cyclohexylammonium salt of (+/-)-1,1-difluoro-3,4-dihydroxybutylphosphonate (9) is described; (9) is a substrate for NADH linked glycerol-3-phosphate dehydrogenase.
FLUORINE IN ENZYME CHEMISTRY PART 21 THE PREPARATION OF DIFLUOROMETHYLENEPHOSPHONATE ANALOGUES OF GLYCOLYTIC PHOSPHATES. APPROACHING AN ISOSTERIC AND ISOELECTRONIC PHOSPHATE MIMIC
Chambers, R. D.,Jaouhari, R.,O'Hagan, D.
, p. 5101 - 5108 (2007/10/02)
The preparation of difluoromethylenephosphonate analogues of the glycolytic intermediates, glycerol-3-phosphate and 3-phosphoglycerate are described.Attempts to prepare the corresponding analogue of dihydroxyacetone phosphate failed due the facile elimina
