1220448-69-0

Basic information

• Product Name: C₁₃H₁₆O₆P^(1-)*Li⁽¹⁺⁾
• CAS NO: 1220448-69-0
• Molecular Weight: 306.181
• Mol File: 1220448-69-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₆O₆P^(1-)*Li⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₆O₆P^(1-)*Li⁽¹⁺⁾(1220448-69-0)
• EPA Substance Registry System: C₁₃H₁₆O₆P^(1-)*Li⁽¹⁺⁾(1220448-69-0)

Safety Data

• Hazardous Substances Data: 1220448-69-0(Hazardous Substances Data)

Upstream product

• 1220448-74-7 C₁₅H₂₁O₆P 
• 41437-17-6 benzyl 4-chloro-4-oxobutanoate 
• 103-40-2 succinic acid monobenzyl ester 

Relevant articles and documents

Succinylphosphonate esters are competitive inhibitors of MenD that show active-site discrimination between homologous α-ketoglutarate- decarboxylating enzymes

MenD is a thiamin diphosphate-dependent enzyme catalyzing the first unique step in menaquinone biosynthesis in bacteria. We have synthesized acylphosphonate ester analogues of a-ketoglutarate, a substrate of MenD. These compounds are competitive inhibitors of MenD, with Ki values as low as 700 nM. Observed structure-activity relationships are in notable contrast to those reported previously for succinylphosphonate inhibition of the a-ketoglutarate dehydrogenase complex, despite the apparent homology of these enzymes, and the identical decarboxylation reactions catalyzed. Inhibiting menaquinone biosynthesis is a proposed approach to inhibiting Mycobacterium tuberculosis growth. These inhibitors showed no significant inhibition of M. tuberculosis growth in vitro under aerobic and hypoxic conditions but give new information about the binding characteristics of the MenD active site. Site-directed mutation of Ser391 to alanine had only a minor effect on catalysis, but even the conservative mutation of Arg395 to lysine had a significant effect on the catalytic processing of isochorismate.