1220461-10-8Relevant articles and documents
Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics
Rashidian, Mohammad,Wang, Lu,Edens, Jerre G.,Jacobsen, Johanne T.,Hossain, Intekhab,Wang, Qifan,Victora, Gabriel D.,Vasdev, Neil,Ploegh, Hidde,Liang, Steven H.
, p. 528 - 533 (2016)
Antibodies are currently the fastest-growing class of therapeutics. Although naked antibodies have proven valuable as pharmaceutical agents, they have some limitations, such as low tissue penetration and a long circulatory half-life. They have been conjugated to toxic payloads, PEGs, or radioisotopes to increase and optimize their therapeutic efficacy. Although nonspecific conjugation is suitable for most in vitro applications, it has become evident that site specifically modified antibodies may have advantages for in vivo applications. Herein we describe a novel approach in which the antibody fragment is tagged with two handles: One for the introduction of a fluorophore or 18F isotope, and the second for further modification of the fragment with a PEG moiety or a second antibody fragment to tune its circulatory half-life or its avidity. Such constructs, which recognize Class II MHC products and CD11b, showed high avidity and specificity. They were used to image cancers and could detect small tumors.
Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography
Hatanaka, Kentaro,Asai, Tomohiro,Koide, Hiroyuki,Kenjo, Eriya,Tsuzuku, Takuma,Harada, Norihiro,Tsukada, Hideo,Oku, Naoto
, p. 756 - 763 (2010)
Pharmacokinetic study of small interfering RNA (siRNA) is an important issue for the development of siRNAs for use as a medicine. For this purpose, a novel and favorable positron emitter-labeled siRNA was prepared by amino group-modification using N-succi
An improved synthesis of n-(4-[18 f]fluorobenzoyl)-interleukin-2 for the preclinical pet imaging of tumour-infiltrating t-cells in ct26 and mc38 colon cancer models
Cheng, Peter,Goggi, Julian L.,Hartimath, Siddesh V.,Jiang, Lingfan,Khanapur, Shivashankar,Narayanaswamy, Pradeep,Ramasamy, Boominathan,Robins, Edward George,Yong, Fui Fong
, (2021)
Positron emission tomography (PET) imaging of activated T-cells with N-(4-[18 F]fluorobenzoyl)-interleukin-2 ([18 F]FB-IL-2) may be a promising tool for patient management to aid in the assessment of clinical responses to immune ther
A facile automated synthesis of N-succinimidyl 4-[18F] fluorobenzoate ([18F]SFB) for18F-labeled cell-penetrating peptide as PET tracer
Tang, Ganghua,Tang, Xiaolan,Wang, Xinlu
, p. 543 - 547 (2010)
A fully automated synthesis of N-succinimidyl 4-[18F] fluorobenzoate ([18F]SFB) was carried out by a convenient three-step, one-pot procedure on the modified TRACERlab FXFN synthesizer, including [18F]fluorinati
A 18f-labeled saxitoxin derivative for in vivo pet-mr imaging of voltage-gated sodium channel expression following nerve injury
Hoehne, Aileen,Behera, Deepak,Parsons, William H.,James, Michelle L.,Shen, Bin,Borgohain, Preeti,Bodapati, Deepika,Prabhakar, Archana,Gambhir, Sanjiv S.,Yeomans, David C.,Biswal, Sandip,Chin, Frederick T.,Bois, J. Du
, p. 18012 - 18015 (2014/01/06)
Both chronic and neuropathic pain conditions are associated with increased expression of certain voltage-gated sodium ion channel (NaV) isoforms in peripheral sensory neurons. A method for noninvasive imaging of these channels could represent a
