1220515-35-4

Upstream product

• 51935-42-3 1-chloro-4-hydrazinophthalazine 
• 52494-54-9 6-chloro-tetrazolo[5,1-a]-phthalazine 
• 106-48-9 4-chloro-phenol 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 4752-10-7 1,4-dichlorophthalazine 

Relevant academic research and scientific papers

Synthesis and primary anticonvulsant activity evaluation of 6-alkyoxyl-tetrazolo[5,1-a]phthalazine derivatives

A new series of 6-alkyoxyl-tetrazolo[5,1-a] phthalazine derivatives (4 a-4 o) were synthesized as potential anticonvulsant agents. Anticonvulsant activity was evaluated by the maximal electroshock (MES) test. Neurotoxicity was evaluated by the rotarod neurotoxicity test. The pharmacological results showed that 6-(4-chlorophenyoxyl)-tetrazolo[5,1-a]phthalazine (4 m) was the most potent agent, with a median effective dose (ED50) of 6.8 mg/kg and a median neurotoxic dose (TD50) of 456.4 mg/kg. The protective index (PI = TD50/ED50) for compound 4m was 67.1, which was significantly higher than that for the reference drug carbamazepine (PI = 6.4). ECV Editio Cantor Verlag.