122052-53-3

Upstream product

• 164414-39-5 acetic acid (1R,4S)-(-)-(tert-butyldimethylsiloxy)cyclohex-2-enyl ester 
• 164414-40-8 cis-(1S,4R)-4-(tert-butyldimethylsilyloxy)cyclohex-2-enol 
• 1165952-91-9 cyclohexa-1,3-diene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 132617-05-1 acetic acid (1S,4R)-(-)-4-hydroxycyclohex-2-enyl ester 
• 122052-52-2 (1S,5R,6R)-5-tert-butyldimethylsilyloxybicyclo<4.1.0>heptan-2-one 
• 74-88-4 methyl iodide 

Downstream Products

• 88418-12-6 (3S,4R,4aR,5R,6R)-sporogen-AO 1 
• 122052-54-4 (2R,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-2,3-dimethyl-2-(3-oxobutyl)cyclohexan-1-one 
• 122074-98-0 (3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-1-trimethylsilanyloxy-cyclohexene 

Relevant academic research and scientific papers

The total synthesis of (+)-petasin and (+)-isopetasin

Petasin 1 and isopetasin 2, anti-inflammatory and analgesic components of the butterbur (Petasites hybridus), were prepared for the first time in a short and enantioselective synthesis. The key steps were a Michael addition/alkylation (7 → 8), an enamine alkylation to give 9 and a cyclization with N-phenyliminoketenylidenetriphenylphosphorane 11 (10 → 15).

EFFICIENT SYNTHESIS OF NATURAL ENANTIOMER OF SPOROGEN-AO 1 (13-DESOXYPHOMENONE), A SPOROGENIC SESQUITERPENE FROM ASPERGILLUS ORYZAE

An efficient total synthesis of (+)-sporogen-AO 1 (13-desoxyphomenone) 1 was achieved in 20 steps from ethyl (1R,2S)-5,5-ethylenedioxy-2-hydroxycyclohexanecarboxylate 3 in 8.3percent overall yield.The optically active 3 with 98.4percent e.e. was easily ob