122055-54-3

Upstream product

• 1963-36-6 4-methoxycinnamaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 1085783-67-0 2-(4-methoxycinnamyl)malononitrile 
• 1449135-99-2 C₃₂H₃₀N₂O₃ 
• 489433-87-6 2,2,3,3-Tetramethoxy-4-[(E)-2-(4-methoxy-phenyl)-vinyl]-cyclobutane-1,1-dicarbonitrile 
• 60983-43-9 (Z)-3-Dicyanomethyl-2,2-dimethoxy-5-(4-methoxy-phenyl)-pent-4-enoic acid methyl ester 

Relevant academic research and scientific papers

[5C + 1N] Annulation of 2,4-pentadienenitriles with hydroxylamine: A synthetic route to multi-substituted 2-aminopyridines

A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH2OH) under very mild conditions, which involves

L-Arginine as a cost-effective and recyclable catalyst for the synthesis of α,β-unsaturated nitriles and ketones in an ionic liquid

L-Arginine catalysed the Knoevenagel condensations of aromatic, heteroaromatic and α,β-unsaturated aldehydes with malononitrile and acetylacetone to afford α,β-unsaturated nitriles and ketones. The reactions were carried out at room temperature in the ionic liquid, 1-ethyl-3-methylimidazolium ethylsulfate. Moderate to excellent yields (45-100%) were achieved. The L-arginine/ionic liquid combination was successfully recycled for fi ve runs without signifi cant loss of activity.