1220572-67-7Relevant articles and documents
Design of a versatile multicomponent reaction leading to 2-amino-5-ketoaryl pyrroles
Wang, Kan,Doemling, Alexander
experimental part, p. 277 - 283 (2010/12/19)
The design of an unprecedented multicomponent reaction to and synthesis of 2-amino-5-ketoaryl pyrroles are described. The compounds (14 examples) can be synthesized by reacting aminoacetophenone sulfonamides, (hetero)aromatic aldehydes, and malonodinitrile or cyanoacetic acid derivatives in one-pot manner. Pharmacophore features and potential applications of this new scaffold are discussed.