1220641-90-6

Upstream product

• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 64824-79-9 4-(phenylsulfonyl)-5-(methylthio)-2H-pyrazol-3-ylamine 
• 243660-91-5 7-chloro-5-methyl-2-methylthio-3-phenylsulfonylpyrazolo[1,5-a]pyrimidine 

Relevant academic research and scientific papers

SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF

The invention relates to the novel substituted 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines of the general formula 1, pharmaceutically acceptable salts and/or hydrates thereof, serotonin 5-HT6 receptor antagonists and pharmaceutical compositions,

Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists

Syntheses of a series of novel 3-sulfonyl-pyrazolo[1,5-a]pyrimidines and their 5-HT6 receptor antagonistic structure-activity relationship are disclosed. The nature and position of substituents, which affect their receptor antagonistic activity