1220702-33-9

Upstream product

• 22532-62-3 4-bromosalicylaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 1335033-07-2 7-bromo-3-[(4-methoxyphenyl)amino]-2H-chromen-2-one 
• 1335033-20-9 7-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-2H-chromen-2-one 

Relevant academic research and scientific papers

A simple synthesis of functionalized 3-bromocoumarins by a one-pot three-component reaction

Functionalized 3-bromocoumarins 2 have been, prepared, by a simple one-pot bromination/Wittig/cyclization tandem process from methyl (triphenylphosphoranylidene)acetate, Nbromosuccinimide and a series of 2-hydroxybenzaldehydes. Owing to the commercial availability of salicylaldehyde derivatives, this approach offers such a diverse range of compounds that it fulfills the recent demand for the generation of large combinatorial chemical libraries based on the coumarin scaffold

Compounds for treating spinal muscular atrophy

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.