1220709-66-9

Upstream product

• 68076-36-8 1-amino-4-[(tert-butyloxycarbonyl)amino]butane 
• 1017967-90-6 C₅₀H₆₁N₃O₁₁ 
• 1017967-84-8 C₅₆H₇₇N₃O₁₀Si 
• 1017967-87-1 C₅₀H₆₃N₃O₁₀ 
• 1220709-65-8 C₅₀H₆₁N₃O₁₀ 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 130432-57-4 2,3-diallyloxybenzoic acid 
• 1017967-83-7 C₁₃H₁₃FO₃ 

Downstream Products

• 1017967-93-9 C₅₄H₇₁N₅O₁₀ 

Relevant academic research and scientific papers

MULTIMODAL CONTRAST AND RADIOPHARMACEUTICAL AGENT FOR AN IMAGING AND A TARGETED THERAPY GUIDED BY IMAGING

A multimodal contrast and radiopharmaceutical agent for an imaging and a targeted therapy guided by imaging.

MULTIMODAL CONTRAST AND RADIOPHARMACEUTICAL AGENT FOR AN IMAGING AND A TARGETED THERAPY GUIDED BY IMAGING

The present invention relates to a multimodal contrast and radiopharmaceutical agent for an imaging and a targeted therapy guided by imaging.

MULTIMODAL CONTRAST AND RADIOPHARMACEUTICAL AGENT FOR AN IMAGING AND A TARGETED THERAPY GUIDED BY IMAGING

The present invention relates to a multimodal contrast and radiopharmaceutical agent for an imaging and a targeted therapy guided by imaging.

Synthesis and characterization of a highly stable dendritic catechol-tripod bearing technetium-99m

The synthesis and preliminary biological tests (in vitro toxicity, in vitro stability) of new Tc(iii)-radiolabelled dendro-chelates are presented. A dendritic 99mTc chelate 1 derived from a pre-organized tripodal tris-catecholamide exhibits a kinetic stability by far more important than its corresponding diethylenetriamine pentaacetic acid (DTPA) homologue 2. This permitted an assessment of the real impact of the pre-organized tripodal structure on kinetic inertness (and thus toxicity), an important issue to address when considering in vivo applications. Radiolabelling was performed using the stannous chloride reduction method; while DTPA-homologue 2 showed a high radiolabelling efficiency (96% radiolabelling yield after 30 min), tripodal complex 1 induced a 93% complexation yield after 45 min. In contrast, radiocomplex 1 derived from the most rigid and organized structure has a higher kinetic stability than 2. Indeed, while dissociation of 2 reached 50% after 1 h 30 min in physiological media like phosphate buffer saline (PBS) and bovine serum albumin (BSA), over 80% of 1 remained stable during the half-life of the radionucleide (6.02 h for 99mTc). Measurements of the cell leakage resulting from membrane damage of neuronal cells treated with increasing concentrations of dendritic ligand 16, together with pictures of treated neurons after staining, showed no detectable toxicity.