Cas 1220710-20-2,6,7-dihydroxy-1,1-dimethyl-1,2,3,4-terahydroisoquinolinium 4-methylbenzenesulfonate

1220710-20-2

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Basic information

Product Name: 6,7-dihydroxy-1,1-dimethyl-1,2,3,4-terahydroisoquinolinium 4-methylbenzenesulfonate
Synonyms: 6,7-dihydroxy-1,1-dimethyl-1,2,3,4-terahydroisoquinolinium 4-methylbenzenesulfonate
CAS NO:1220710-20-2
Molecular Formula:
Molecular Weight: 365.45
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 6,7-dihydroxy-1,1-dimethyl-1,2,3,4-terahydroisoquinolinium 4-methylbenzenesulfonate(CAS DataBase Reference)
NIST Chemistry Reference: 6,7-dihydroxy-1,1-dimethyl-1,2,3,4-terahydroisoquinolinium 4-methylbenzenesulfonate(1220710-20-2)
EPA Substance Registry System: 6,7-dihydroxy-1,1-dimethyl-1,2,3,4-terahydroisoquinolinium 4-methylbenzenesulfonate(1220710-20-2)

Safety Data

Hazard Codes: N/A
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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1220710-20-2(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1220710-20-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,0,7,1 and 0 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1220710-20:
(9*1)+(8*2)+(7*2)+(6*0)+(5*7)+(4*1)+(3*0)+(2*2)+(1*0)=82
82 % 10 = 2
So 1220710-20-2 is a valid CAS Registry Number.

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1220710-20-2Relevant academic research and scientific papers

Acetonide protection of dopamine for the synthesis of highly pure N-docosahexaenoyldopamine

Liu, Zhongqiang,Hu, Bi-Huang,Messersmith, Phillip B.

, p. 2403 - 2405 (2010)

Direct acetonide protection of the catechol of dopamine has proven to be problematic due to the formation of Pictet-Spengler isoquinolines. Here we report an efficient method for acetonide protection of dopamine, allowing the preparation of a dopamine prodrug without complications from the Pictet-Spengler reaction. Acetonide-protected dopamine was first synthesized by pre-protecting the amino group with phthaloyl followed by refluxing with 2,2-dimethoxypropane in the presence of TsOH. Further work demonstrated that Fmoc and trifluoroacetyl were also suitable N-protective groups, while Boc-protected dopamine gave an isoquinoline product. Acetonide-protected dopamine was coupled to DHA (all cis-4,7,10,13,16,19-docosahexaenoic acid) to produce the N-DHA-dopamine prodrug with high purity.

Method of synthesizing acetonide-protected catechol-containing compounds and intermediates produced therein

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Page/Page column 26, (2012/07/30)

The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. In specific embodiments, the invention provides novel methods of synthesizing 3,4-dihydroxyphenylalanine (H-DOPA(acetonide)-OH (6)), Fmoc-protected H-DOPA(acetonide)-OH (Fmoc-DOPA(acetonide)-OH (7)), Fmoc-protected dopamine (Fmoc-dopamine(acetonide) (10)), TFA-protected dopamine (TFA-dopamine(acetonide) (13)) and acetonide-protected 4-(2-aminoethyl)benzene-1,2-diol (acetonide-protected dopamine (14)).

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