1220748-74-2Relevant academic research and scientific papers
Synthesis and biological evaluation of new tacrine analogues under microwave irradiation
Alshareef, Hossa Fahad,Mohamed, Heba Abd El Hady,Salaheldin, Abdellatif Mohamed
, p. 732 - 738 (2017/08/09)
Efficient routes to various kinds of heterocycles incorporating the p-halophenyl moiety have been synthesized. Different pyrrole derivatives have been synthesized, as well, by Thorpe–Ziegler cyclization. Therefore, we synthesized different analogues of tacrine by Friedl?nder reaction of o-amino nitriles (pyrazolo, furano and pyrrolo) with different cycloalkanones. The use of microwave irradiation leads to shorter production times and high product conversion. These synthesized compounds were biologically evaluated by Ellman’s test on acetylcholinesterase inhibition.
Synthesis of new tacrine analogues from 4-amino-1H-pyrrole-3-carbonitrile
Salaheldin, Abdellatif M.,Oliveira-Campos, Ana M. F.,Parpot, Pier,Rodrigues, Ligia M.,Oliveira, M. Manuel,Feixoto, Francisco P.
experimental part, p. 242 - 248 (2010/05/15)
An easy preparation of 4-amino-1H-pyrrole-3-carbonitrile derivatives and their transformation into new substituted pyrrolo[3,2-b]pyridines is described. The one-step transformation was carried out via Friedlaender reaction under microwave irradiation and
