122078-09-5

Basic information

• Product Name: Benzenemethanamine, 2,3,4-trimethoxy-a-methyl-,(S)-
• Synonyms: Benzenemethanamine, 2,3,4-trimethoxy-a-methyl-,(S)-;Benzenemethanamine, 2,3,4-trimethoxy-α-methyl-, (S)- (9CI);4-triMethoxy-a-Methyl-;(1S)-1-(2,3,4-TRIMETHOXYPHENYL)ETHYLAMINE
• CAS NO: 122078-09-5
• Molecular Formula: C₁₁H₁₇NO₃
• Molecular Weight: 211.26
• Product Categories: API intermediates
• Mol File: 122078-09-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 314.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.063±0.06 g/cm3(Predicted)
• PKA: 9.26±0.10(Predicted)
• CAS DataBase Reference: Benzenemethanamine, 2,3,4-trimethoxy-a-methyl-,(S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 2,3,4-trimethoxy-a-methyl-,(S)-(122078-09-5)
• EPA Substance Registry System: Benzenemethanamine, 2,3,4-trimethoxy-a-methyl-,(S)-(122078-09-5)

Safety Data

• Hazardous Substances Data: 122078-09-5(Hazardous Substances Data)

Usage

General Description

Benzenemethanamine, 2,3,4-trimethoxy-a-methyl-,(S)- is a chemical compound with the molecular formula C11H17NO3. It is also known as (S)-2,3,4-trimethoxy-alpha-methylbenzylamine and is derived from the natural product ephedrine. Benzenemethanamine, 2,3,4-trimethoxy-a-methyl-,(S)- is a chiral molecule, meaning it has a non-superimposable mirror image. It is commonly used in the synthesis of various pharmaceutical drugs and can also be used as a precursor for the production of other organic compounds. It has potential applications in the pharmaceutical and chemical industries due to its unique structure and properties.

Upstream product

• 122078-22-2 (1S,1'S)-N-(1'-phenylethyl)-1-(2'',3'',4''-trimethoxyphenyl)ethylamine 

Downstream Products

• 128134-45-2 N-(2,4-dinitrosulfenyl)-4-methyl-N-<1-(2,3,4-trimethoxyphenyl)ethyl>benzenesulfonamide 

Relevant articles and documents

Chiral Building Blocks for the Synthesis of Nitrogen-Containing Natural Products, 5. The Enantioselective Synthesis of Optically Active, Benzene Nucleus-Substituted 1-Phenylethylamines from the Corresponding Acetophenones

An efficient two-step procedure for the synthesis of enantiomerically pure, benzene nucleus-substituted 1-phenylethylamines 1 is described, with predictable absolute configuration at the stereogenic center: Imine formation from the substituted acetophenones 6 with (S)- or (R)-1-phenylethylamine and subsequent hydrogenation of the resulting Schiff bases 8 over Raney nickel leads to the secondary amines 9 and 10 in high diastereoselectivities.These dibenzylamines are cleaved regioselectively, usually next to the less substituted aromatic ring, giving the desired chiral 1-phenylethylamines 1 in high yields and enantiomeric purities.Scope and limitations of this new and facile approach to the versatile building blocks 1 are reported.