1220829-75-3Relevant academic research and scientific papers
Improved enantioselective synthesis of (?)-linderol A: Hindered rotation about aryl?Csp3 bond
Delaye, Pierre-Olivier,Lameiras, Pedro,Kervarec, Nelly,Mirand, Catherine,Berber, Hatice
experimental part, p. 2501 - 2509 (2010/07/09)
An improved enantioselective total synthesis of (?)-linderol A has been achieved via a five-step reaction with a 21% overall yield, starting from phloroacetophenone and (?)-α-phellandrene, two commercially available reagents. In the diastereoselective epoxidation step, the analysis of the two endocyclic epoxide intermediates reveals a hindered sp2?sp 3 rotation, which results in rotational diastereoisomers.
