1220893-63-9Relevant academic research and scientific papers
Total Synthesis of Ileabethoxazole, Pseudopteroxazole, and seco-Pseudopteroxazole
Yang, Ming,Yang, Xiaowen,Sun, Hongbin,Li, Ang
supporting information, p. 2851 - 2855 (2016/02/26)
The total syntheses of ileabethoxazole, pseudopteroxazole, and seco-pseudopteroxazole, three antituberculosis diterpenoids that had been isolated from Pseudopterogorgia elisabethae, were accomplished in a collective fashion. A cascade alkyne carbopalladation/Stille reaction was exploited to construct a triene precursor with suitable geometry. A fully substituted arene was then assembled through a key 6π electrocyclization/aromatization sequence, and served as an advanced common intermediate. Two radical cyclizations led to the formation of the five- and six-membered rings of ileabethoxazole and pseudopteroxazole, respectively, with the desired stereochemistry, and a straightforward side-chain elongation delivered seco-pseudopteroxazole.
Synthesis of a key intermediate for the total synthesis of pseudopteroxazole
Yadav,Bhasker, E. Vijaya,Srihari
experimental part, p. 1997 - 2004 (2010/04/29)
A facile synthesis of a key intermediate for the total synthesis of anti-mycobacterial compound pseudopteroxazole is described employing an intramolecular Diels-Alder cyclization and an iodine-mediated oxidative aromatization step.
