1220999-80-3Relevant articles and documents
Chiral, non-racemic diols, and α-amino acid-derived β-amino alcohols as templates for chiral catalysts in the Tsuji-Trost reaction
Mahadik, Geetanjali S.,Hitchcock, Shawn R.
experimental part, p. 33 - 38 (2010/04/24)
A commercially available collection of β-amino alcohols have been converted to their corresponding β-(o-diphenylphosphino) benzoyloxy(o-diphenylphosphino) benzamides and have been employed in the Tsuji-Trost asymmetric alkylation reaction with 1,3-diphenylpropenyl acetate. The best ligand was derived from l-tert-leucinol and when applied to the asymmetric allylic alkylation reaction, yielded the product in an enantiomeric ratio of 99.5:0.5 favoring the (S)-enantiomer.
