1221065-75-3Relevant academic research and scientific papers
Enantioselective alkenylation via nickel-catalyzed cross-coupling with organozirconium reagents
Lou, Sha,Fu, Gregory C.
supporting information; experimental part, p. 5010 - 5011 (2010/06/14)
A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary a-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon-carbon bond-forming process that generates potentially labile β,-unsaturated ketones with good enantioselectivity.
