1221065-91-3Relevant academic research and scientific papers
Enantioselective alkenylation via nickel-catalyzed cross-coupling with organozirconium reagents
Lou, Sha,Fu, Gregory C.
supporting information; experimental part, p. 5010 - 5011 (2010/06/14)
A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary a-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon-carbon bond-forming process that generates potentially labile β,-unsaturated ketones with good enantioselectivity.
Palladium-Catalyzed Reaction of Acyliron Complexes with Aryl Halydes. A Convenient Synthesis of Aromatic Ketones
Koga, Teruyoshi,Makinouchi, Shinako,Okukado, Nobuhisa
, p. 1141 - 1144 (2007/10/02)
Acyliron complexes, easily prepared from disodium tetracarbonylferrate and alkyl halides, reacted with aryl iodides in the presence of a catalytic amount of Pd(PPh3)4 and a cocatalyst, ZnCl2, to give aromatic ketones in good yields. (R)-2-Methyl-1-phenyl-octanone was prepared starting from (S)-2-bromooctane in an excellent optical yield.
The Stereochemistry of Alkylation of α-Aminonitrile Anions by Chiral 1-Methylheptyl Halides
Chauffaille, Jean,Hebert, Eric,Welvart, Zoltan
, p. 1645 - 1648 (2007/10/02)
The alkylation of the α-dimethylaminophenylacetonitrile with chiral 1-methylheptyl halides in liquid ammonia involves a partial inversion of the configuration.The accompanying racemization is dependent on the basic reagent and is the consequence of partia
