1221153-86-1 Usage
Description
4-(1-isopropyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyriMidin-2-ol, also known as CPI-0610, is a chemical compound with potential pharmacological properties. It is a selective inhibitor of bromodomain and extra-terminal (BET) proteins, which are involved in the regulation of gene expression. BET proteins have been implicated in various diseases, including cancer and inflammatory disorders, making them attractive targets for drug development.
Used in Pharmaceutical Industry:
4-(1-isopropyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyriMidin-2-ol is used as a therapeutic agent for the treatment of hematologic malignancies, such as myelofibrosis and acute myeloid leukemia. It modulates gene expression and inhibits tumor growth, showing promise in preclinical studies.
Used in Clinical Research:
4-(1-isopropyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyriMidin-2-ol is used as a potential therapeutic agent in ongoing clinical trials to further evaluate its safety and efficacy for the treatment of hematologic malignancies.
Check Digit Verification of cas no
The CAS Registry Mumber 1221153-86-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,1,1,5 and 3 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1221153-86:
(9*1)+(8*2)+(7*2)+(6*1)+(5*1)+(4*5)+(3*3)+(2*8)+(1*6)=101
101 % 10 = 1
So 1221153-86-1 is a valid CAS Registry Number.
1221153-86-1Relevant articles and documents
NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY
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Page/Page column 65, (2010/04/28)
The present invention relates to a compound of formula I: wherein: R1 is C1-6 alkyl, C3-8 cycloalkyl, aryl, heterocyclyl, or -COR1x, where the C1-6 alkyl, C3-8 cycloalkyl, aryl, and heterocyclyl may be substituted; and R1x is C3-8 cycloalkyl, aryl, or heterocyclyl, any of which may be substituted; R2, R3, R4, R5, R6, and R7 are each independently hydrogen, halogen, C1-6 alkyl, or aryl, where the C1-6 alkyl or aryl may be substituted; R8 is hydrogen, C1-6 alkyl, aryl, or heterocyclyl, any of which may be substituted; or a pharmaceutically acceptable salt or ester thereof.
