1221160-66-2

Basic information

• Product Name: 2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetonitrile
• CAS NO: 1221160-66-2
• Molecular Weight: 199.252
• Mol File: 1221160-66-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetonitrile(1221160-66-2)
• EPA Substance Registry System: 2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetonitrile(1221160-66-2)

Safety Data

• Hazardous Substances Data: 1221160-66-2(Hazardous Substances Data)

Upstream product

• 196597-79-2 (E)-2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile 
• 1217272-33-7 1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylacetonitrile 

Relevant articles and documents

Concise Six-Step Asymmetric Approach to Ramelteon from an Acetophenone Derivative Using Ir, Rh, Cu, and Ni Catalysis

A concise six-step asymmetric synthesis of nearly enantiomerically pure ramelteon was developed from a monocyclic precursor with a 17% overall yield and a 97% ee in the asymmetric step. The synthetically challenging tricyclic 1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan core of ramelteon was assembled by using Ir-catalyzed O-vinylation and Rh-catalyzed vinyl ether annulation through directed C-H bond activation, while the chirality was introduced with enantioselective reduction of an α,β-unsaturated nitrile moiety under hydrosilylation conditions using a CuII/Walphos type catalyst. The presented methodology represents the shortest synthetic approach to ramelteon.

PROCESS FOR PREPARATION OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO[5,4-B]FURAN-8-YL)ETHYL] PROPIONAMIDE AND NOVEL INTERMEDIATES THEREOF

Disclosed herein process for preparation of (S)-Ramelteon and intermediates thereof.