1221171-94-3

Basic information

• Product Name: 2-(TrifluoroMethoxy)pyridin-3-aMine
• Synonyms: 2-(TrifluoroMethoxy)pyridin-3-aMine
• CAS NO: 1221171-94-3
• Molecular Formula: C6H5F3N2O
• Molecular Weight: 178.1119096
• Mol File: 1221171-94-3.mol

Chemical Properties

• Boiling Point: 189.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.421±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.75±0.29(Predicted)
• CAS DataBase Reference: 2-(TrifluoroMethoxy)pyridin-3-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TrifluoroMethoxy)pyridin-3-aMine(1221171-94-3)
• EPA Substance Registry System: 2-(TrifluoroMethoxy)pyridin-3-aMine(1221171-94-3)

Safety Data

• Hazardous Substances Data: 1221171-94-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
2-(TrifluoroMethoxy)pyridin-3-aMine is used as a building block for the synthesis of various biologically active molecules, contributing to the development of new pharmaceutical agents.
Used in Antiviral Applications:
2-(TrifluoroMethoxy)pyridin-3-aMine is studied for its potential antiviral properties, offering a promising avenue for the development of antiviral drugs.
Used in Antitumor Applications:
2-(TrifluoroMethoxy)pyridin-3-aMine is also being investigated for its potential antitumor properties, which could lead to the creation of novel cancer treatments.
Used in Organic Synthesis and Medicinal Chemistry:
Due to its strong electron-withdrawing properties, 2-(TrifluoroMethoxy)pyridin-3-aMine is utilized in organic synthesis and medicinal chemistry applications, enhancing the reactivity and selectivity of chemical reactions.

Upstream product

• 1221171-93-2 5-amino-2-chloro-6-(trifluoromethoxy)pyridine 

Relevant articles and documents

METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES

The present invention pertains to a process for the preparation of functionalized trihalomethoxypyridines of formula (I) comprising reacting hydroxypyridines with thiophosgene in the presence of a base; reacting the obtained chlorothionoformiates with elemental chlorine and finally converting trichloromethoxy pyridines to trihalomethoxy pyridines using a fluoride source.

A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies. A general and efficient route to (trifluoromethoxy)pyridines is reported. Regioselective functionalization by organometallic methods afforded new and highly important building blocks for life-sciences-oriented research. The first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed and supported by in silico studies.