1221171-96-5

Basic information

• Product Name: 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine
• Synonyms: 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine
• CAS NO: 1221171-96-5
• Molecular Formula: C₆H₂ClF₃INO
• Molecular Weight: 323.4388596
• EINECS: -0
• Mol File: 1221171-96-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine(1221171-96-5)
• EPA Substance Registry System: 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine(1221171-96-5)

Safety Data

• Hazardous Substances Data: 1221171-96-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine is used as a key intermediate in the synthesis of pharmaceutical compounds for its ability to contribute to the development of new molecules with potential therapeutic effects. Its unique structural features allow for the creation of diverse drug candidates that can target specific biological pathways.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine is employed as a precursor in the production of pesticides and other agrochemicals, leveraging its reactivity to form molecules with pesticidal properties, thereby contributing to crop protection and yield enhancement.
Used in Material Science:
2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine is utilized in material science applications as a component in the development of new materials with specific properties. Its incorporation into polymers and other materials can lead to advancements in areas such as electronics, coatings, and advanced materials with tailored characteristics for various industrial uses.

Upstream product

• 1221171-95-4 2-chloro-5-iodo-6-(trifluoromethoxy)pyridine 

Downstream Products

• 1221171-97-6 6-chloro-2-(trifluoromethoxy)isonicotinic acid 

Relevant articles and documents

METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES

The present invention pertains to a process for the preparation of functionalized trihalomethoxypyridines of formula (I) comprising reacting hydroxypyridines with thiophosgene in the presence of a base; reacting the obtained chlorothionoformiates with elemental chlorine and finally converting trichloromethoxy pyridines to trihalomethoxy pyridines using a fluoride source.

A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies. A general and efficient route to (trifluoromethoxy)pyridines is reported. Regioselective functionalization by organometallic methods afforded new and highly important building blocks for life-sciences-oriented research. The first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed and supported by in silico studies.