1221172-04-8

Basic information

• Product Name: 2-chloro-6-(trifluoroMethoxy)nicotinic acid
• Synonyms: 2-chloro-6-(trifluoroMethoxy)nicotinic acid
• CAS NO: 1221172-04-8
• Molecular Formula: C₇H₃ClF₃NO₃
• Molecular Weight: 241.5518296
• Mol File: 1221172-04-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 261.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.637±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.62±0.28(Predicted)
• CAS DataBase Reference: 2-chloro-6-(trifluoroMethoxy)nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-(trifluoroMethoxy)nicotinic acid(1221172-04-8)
• EPA Substance Registry System: 2-chloro-6-(trifluoroMethoxy)nicotinic acid(1221172-04-8)

Safety Data

• Hazardous Substances Data: 1221172-04-8(Hazardous Substances Data)

Usage

General Description

2-chloro-6-(trifluoromethoxy)nicotinic acid is a chemical compound with the molecular formula C7H4ClF3NO3. It is a derivative of nicotinic acid, also known as vitamin B3, and contains a chlorine atom and a trifluoromethoxy group attached to the nicotinic acid structure. 2-chloro-6-(trifluoromethoxy)nicotinic acid is used in the synthesis of pharmaceuticals and agrochemicals, and it exhibits strong fungicidal and herbicidal properties. It has potential applications in the development of new drugs and agricultural products due to its unique chemical structure and biological activity. Additionally, its properties may also make it useful in other industrial or research applications where a compound with similar characteristics is required.

Upstream product

• 16879-02-0 6-chloro-2-pyridone 
• 124-38-9 carbon dioxide 
• 1221172-02-6 2-chloro-6-(trifluoromethoxy)-5-(trimethylsilyl)pyridine 
• 1221171-69-2 2-chloro-6-(trichloromethoxy)pyridine 
• 1221171-70-5 2-chloro-6-(trifluoromethoxy)pyridine 
• 16879-02-0 6-chloro-2-hydroxypyridine 
• 1384878-23-2 2-chloro-6-(trifluoromethoxy)-5-(trimethylsilyl)nicotinic acid 

Downstream Products

• 940895-85-2 6-(trifluoromethoxy)nicotinic acid 
• 1384878-12-9 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5(R)-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one 
• 1384878-11-8 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5(S)-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one 
• 1384878-02-7 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one 

Relevant articles and documents

2-AMINO-N-PHENYL-NICOTINAMIDES AS NAV1.8 INHIBITORS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

1-(6-MEMBERED AZO-HETEROCYCLIC)-2,5-DIHYDRO-1H-PYRROL-2-ONE DERIVATIVES AS ANTI-HEPATITIS C VIRUS, THE PHARMACEUTICAL COMPOSITION THEREOF AND THEIR THERAPEUTIC USE

The present invention concerns 1-(6-memberedazo-heterocyclic)-2,5-dihydro–1H–pyrrol–2-one compoundsof the following formula (I) or a salt, solvate, tautomer, isotope, enantiomer, diastereoisomer or racemic mixture thereof: the pharmaceutical composition thereof and their therapeutic use as inhibitors of Hepatitis C virus.

A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies. A general and efficient route to (trifluoromethoxy)pyridines is reported. Regioselective functionalization by organometallic methods afforded new and highly important building blocks for life-sciences-oriented research. The first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed and supported by in silico studies.