1221186-54-4

Basic information

• Product Name: ethyl 2-broMo-6-forMyl-4H-thieno[3,2-b]pyrrole-5-carboxylate
• Synonyms: ethyl 2-broMo-6-forMyl-4H-thieno[3,2-b]pyrrole-5-carboxylate;4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, 2-bromo-6-formyl-, ethyl ester;2-Bromo-6-formyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyl ester
• CAS NO: 1221186-54-4
• Molecular Formula: C10H8BrNO3S
• Molecular Weight: 302.14442
• Mol File: 1221186-54-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-broMo-6-forMyl-4H-thieno[3,2-b]pyrrole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-broMo-6-forMyl-4H-thieno[3,2-b]pyrrole-5-carboxylate(1221186-54-4)
• EPA Substance Registry System: ethyl 2-broMo-6-forMyl-4H-thieno[3,2-b]pyrrole-5-carboxylate(1221186-54-4)

Safety Data

• Hazardous Substances Data: 1221186-54-4(Hazardous Substances Data)

Usage

General Description

Ethyl 2-bromo-6-formyl-4H-thieno[3,2-b]pyrrole-5-carboxylate is a chemical compound with the formula C11H9BrNO3S. It is a derivative of thieno[3,2-b]pyrrole, which is a heterocyclic compound with a sulfur and nitrogen atom in the ring structure. This chemical is an ester, containing an ethyl group and a carboxylate group, as well as a bromine atom and a formyl group. It is commonly used as a building block in organic synthesis, and its structural and functional properties make it suitable for various research and industrial applications in the field of organic chemistry.

Upstream product

• 238749-50-3 ethyl 2-bromothieno<3,2-b>pyrrole-5-carboxylate 
• 93-61-8 N-methyl-N-phenylformamide 
• 1421933-23-4 ethyl (Z)-2-azido-3-(5-bromo-2-thienyl)prop-2-enoate 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1221186-55-5 ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate 
• 1221186-56-6 2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one 

Relevant articles and documents

THIENO[3,2-B] PYRROLE[3,2-D]PYRIDAZINONE DERIVATIVES AND THEIR USE AS PKM2 DERIVATIVES FOR THE TREATMENT OF CANCER, OBESITY AND DIABETES RELATED DISORDERS

Described herein are compounds that regulate pyruvate kinase activity, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R2, L1-L2, U1-U7, m, ring A, and Q are as defined herein.

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

Cancer cells have distinct metabolic needs that are different from normal cells and can be exploited for development of anti-cancer therapeutics. Activation of the tumor specific M2 form of pyruvate kinase (PKM2) is a potential strategy for returning cancer cells to a metabolic state characteristic of normal cells. Here, we describe activators of PKM2 based upon a substituted thieno[3,2-b]pyrrole[3,2-d]pyridazinone scaffold. The synthesis of these agents, structure-activity relationships, analysis of activity at related targets (PKM1, PKR and PKL) and examination of aqueous solubility are investigated. These agents represent the second reported chemotype for activation of PKM2.