1221186-55-5

Basic information

• Product Name: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate
• Synonyms: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate;4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, 2-bromo-6-formyl-4-methyl-, ethyl ester;2-Bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyl ester
• CAS NO: 1221186-55-5
• Molecular Formula: C11H10BrNO3S
• Molecular Weight: 316.171
• Mol File: 1221186-55-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate(1221186-55-5)
• EPA Substance Registry System: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate(1221186-55-5)

Safety Data

• Hazardous Substances Data: 1221186-55-5(Hazardous Substances Data)

Usage

General Description

Ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate is a chemical compound with a complex molecular structure. It contains an ethyl ester group, a bromine atom, a formyl group, and a carboxylate group, as well as a thieno[3,2-b]pyrrole ring system. This chemical compound has potential applications in pharmaceutical research and drug development, as well as in the field of organic synthesis. Due to its unique structure and properties, it may exhibit interesting biological activities and could be of interest for further study in medicinal chemistry and related scientific disciplines.

Upstream product

• 238749-50-3 ethyl 2-bromothieno<3,2-b>pyrrole-5-carboxylate 
• 1421933-23-4 ethyl (Z)-2-azido-3-(5-bromo-2-thienyl)prop-2-enoate 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 1221186-54-4 ethyl 2-bromo-6-formyl-4H-thieno[3,2-b]pyrrole-5-carboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 1221186-56-6 2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one 

Relevant articles and documents

THIENO[3,2-B] PYRROLE[3,2-D]PYRIDAZINONE DERIVATIVES AND THEIR USE AS PKM2 DERIVATIVES FOR THE TREATMENT OF CANCER, OBESITY AND DIABETES RELATED DISORDERS

Described herein are compounds that regulate pyruvate kinase activity, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R2, L1-L2, U1-U7, m, ring A, and Q are as defined herein.

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

Cancer cells have distinct metabolic needs that are different from normal cells and can be exploited for development of anti-cancer therapeutics. Activation of the tumor specific M2 form of pyruvate kinase (PKM2) is a potential strategy for returning cancer cells to a metabolic state characteristic of normal cells. Here, we describe activators of PKM2 based upon a substituted thieno[3,2-b]pyrrole[3,2-d]pyridazinone scaffold. The synthesis of these agents, structure-activity relationships, analysis of activity at related targets (PKM1, PKR and PKL) and examination of aqueous solubility are investigated. These agents represent the second reported chemotype for activation of PKM2.