1221265-82-2Relevant academic research and scientific papers
Amaranzoles B?F, imidazole-2-carboxy steroids from the marine sponge phorbas amaranthus. C24- N - And C24- O -analogues from a divergent oxidative biosynthesis
Morinaka, Brandon I.,Pawlik, Joseph R.,Molinski, Tadeusz F.
experimental part, p. 2453 - 2460 (2010/07/17)
Five new steroidal imidazoles, amaranzoles B?F, were isolated from extracts of the marine sponge Phorbas amaranthus along with the known amaranzole A. The C24-N-(4-p-hydroxyphenyl)imidazol-5-yl constitution found in amaranzoles A, C, and D is replaced by a C24-O-(4-p-hydroxyphenyl)imidazole-2-carboxylate motif in amaranzoles B, E, and F. The structures were elucidated by interpretation of spectroscopic data. The C24 side chain configuration was assigned by synthesis of a model ester followed by chiroptical comparisons of its CD spectrum with that of an amaranzole B derivative.
