1221277-42-4

Basic information

• Product Name: (2-phenyl-1H-imidazol-4-yl)(piperidin-1-yl)methanone
• Synonyms: (2-phenyl-1H-imidazol-4-yl)(piperidin-1-yl)methanone
• CAS NO: 1221277-42-4
• Molecular Weight: 255.319
• Mol File: 1221277-42-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-phenyl-1H-imidazol-4-yl)(piperidin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-phenyl-1H-imidazol-4-yl)(piperidin-1-yl)methanone(1221277-42-4)
• EPA Substance Registry System: (2-phenyl-1H-imidazol-4-yl)(piperidin-1-yl)methanone(1221277-42-4)

Safety Data

• Hazardous Substances Data: 1221277-42-4(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 33469-36-2 2-phenyl-4-(trifluoromethyl)-1H-imidazole 

Relevant articles and documents

Synthesis of tertiary amides from anionically activated aromatic trifluoromethyl groups

Figure presented In this paper, a novel synthesis of tertiary amides from anionically activated aromatic trifluoromethyl groups is presented. Anionically activated trifluoromethyl groups react with secondary amines under aqueous conditions to afford tertiary amides. The mechanism involves initial elimination of hydrogen fluoride by an E1cB mechanism to afford an electrophilic quinone methide- or azafulvene-type intermediate that reacts with secondary amines under aqueous conditions to afford the tertiary amide in good yield (up to 99%).