1221282-91-2Relevant academic research and scientific papers
Hetero-Tetradehydro-Diels-Alder Cycloaddition of Enynamides and Cyanamides: Gold-Catalyzed Generation of Diversely Substituted 2,6-Diaminopyridines
Shcherbakov, Nikolay V.,Dar'In, Dmitry V.,Kukushkin, Vadim Yu.,Dubovtsev, Alexey Yu.
, p. 7218 - 7228 (2021/05/29)
Gold(I)-catalyzed hetero-tetradehydro-Diels-Alder cycloaddition of enynamides and cyanamides comprises an efficient route to diversely substituted 2,6-diaminopyridines (28 examples; yields up to 99%). The reaction proceeds under very mild conditions (DCM, rt) with high functional group tolerance. The obtained 2,6-diaminopyridines represent a useful synthetic platform with an easily modulated substitution pattern for subsequent functionalizations of both the pyridine core and the N-substituents.
Cu-catalyzed oxidative amidation of propiolic acids under air via decarboxylative coupling
Jia, Wei,Jiao, Ning
supporting information; experimental part, p. 2000 - 2003 (2010/07/03)
Figure presented A Cu-catalyzed aerobic oxidative amidation of propiolic acids via decarboxylation under air has been developed. Only carbon dioxide is produced as byproduct in this approach. The use of air as oxidant makes this method more useful and easy to handle.
