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1221398-11-3

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1221398-11-3 Usage

General Description

6-Chloro-5-iodopyridin-2-amine is a chemical compound, also identified by the CAS number 884494-34-3. This chemical is significant typically in the domain of pharmaceutical research and chemical synthesis where it can behave as a reagent or intermediate. The two halogens in its structure, chlorine and iodine, can participate in various chemical reactions, making it versatile for the synthesis of a wide range of substances. Detailed information about its physical and chemical properties such as melting points, boiling points, density, etc., might vary and need to be verified from its specific product data sheet. As with all chemicals, appropriate handling and disposal methods should be used to ensure safety.

Check Digit Verification of cas no

The CAS Registry Mumber 1221398-11-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,1,3,9 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1221398-11:
(9*1)+(8*2)+(7*2)+(6*1)+(5*3)+(4*9)+(3*8)+(2*1)+(1*1)=123
123 % 10 = 3
So 1221398-11-3 is a valid CAS Registry Number.

1221398-11-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Chloro-5-iodopyridin-2-amine

1.2 Other means of identification

Product number -
Other names 6-chloro-5-iodopyridin-2-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1221398-11-3 SDS

1221398-11-3Upstream product

1221398-11-3Downstream Products

1221398-11-3Relevant articles and documents

Method for preparing 6-chlorine-5-trifluoromethyl-2-aminopyridine

-

Paragraph 0007-0008, (2019/06/07)

The invention provides a method for preparing 6-chlorine-5-trifluoromethyl-2-aminopyridine. According to the method, a product is obtained by taking 6-chlorine-5-iodine-2-aminopyridine as a raw material and adopting reaction steps such as amino protection, trifiuoroniethylation and deprotection.

Ligand structure includes a new metal complexes

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Paragraph 0332; 0333; 0334, (2016/11/24)

Compounds comprising a metal complex having novel ligands are provided. In particular, the compound is an iridium complex comprising novel aza DBX ligands. The compounds may be used in organic light emitting devices, particularly as emitting dopants, providing improved efficiency, low operating voltage, and long lifetime.

Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABAA receptor agonists

Petersen, Jette G.,S?rensen, Troels,Damgaard, Maria,Nielsen, Birgitte,Jensen, Anders A.,Balle, Thomas,Bergmann, Rikke,Fr?lund, Bente

, p. 404 - 416 (2014/08/05)

A series of 6-aminonicotinic acid analogues have been synthesized and pharmacologically characterized at native and selected recombinant GABA A receptors. 6-Aminonicotinic acid (3) as well as 2- and 4-alkylated analogues (9-11, 14-16) display low to mid-micromolar GABAAR binding affinities to native GABAA receptors (Ki 1.1-24 μM). The tetrahydropyridine analogue of 3 (22) shows low-nanomolar affinity (K i 0.044 μM) and equipotency as an agonist to GABA itself as well as the standard GABAA agonist isoguvacine. Cavities surrounding the core of the GABA binding pocket were predicted by molecular interaction field calculations and docking studies in a α1β 2γ2 GABAA receptor homology model, and were confirmed by affinities of substituted analogues of 3. The tight steric requirements observed for the remarkably few GABAAR agonists reported to date is challenged by our findings. New openings for agonist design are proposed which potentially could facilitate the exploration of different pharmacological profiles within the GABAAR area.

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